By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

ISBN-10: 1461290643

ISBN-13: 9781461290643

ISBN-10: 1461319137

ISBN-13: 9781461319139

The manuscripts during this quantity have been contributed through the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly used to be geared up to commemorate the outline of acromegaly by way of the French health practitioner Pierre Marie, in 1886. The participants of the medical Committee spent many hours helping us in making sure an exceptional assembly. The help of Serono Symposia, united states in all levels of the making plans and execution of the assembly used to be basically liked and was once hugely specialist. unique attractiveness roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in clinical historical past led him to dedicate loads of time and private price in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the lifestyles and instances of Marie was once a rare assessment of the cultural, social, and clinical backgrounds within which Marie got here to explain the ailment, acromegaly. Dr. Guillemin' s findings, that have been provided on the major ceremonial dinner in a the best option audiovisual presentation, have been essentially the spotlight of the assembly and may lengthy be remembered by means of the attendees. We have been additionally commemorated through the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her tackle on the dinner party, Dr. Granier supplied numerous pleasant and intimate vignettes touching on Pierre Marie, utilizing previous family members documents and images. The medical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the ancient surroundings of the meeting.

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A single intron is located within the E region and, thus, only one IGF-II precursor peptide is predicted; another intron is located 6 bp 5' to the start of the IGF-II gene. There is minimal homology between the IGF-II E peptide and the IGF-I E domains, but the IGF-II E region is highly conserved (79%) between the human and the rat. This conservation suggests that this carboxyl terminal fragment may in fact have a biological function. Recently, Hylka and co-workers confirmed the presence of an immunoreactive E peptide in medium from BRL-3A cells and showed that a synthetic IGF-II E-region peptide stimulated the incorporation of [3H]-thymidine in NIL8 hamster cells (19).

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Amsterdam: Excerpta Medica, 1981. Hampson RK, Rottman FM. A potential variant of bovine growth hormone resulting from non-splicing of an intron. Fed Proc 1986; 45:1703. Singh RNP, Seavey BK, Rice VP, Lindsey TT, Lewis UJ. Modified forms of human growth hormone with increased biological activities. Endocrinology 1974; 94:883. The human growth hormone gene family: nucleotide Seeburg PH. sequences show recent divergence and predict a new polypeptide hormone. DNA 1982; 1:239. Sinha YN, Lewis UJ. Detection of glycosylated growth hormone in the human pituitary gland.

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Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)


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