By Rodolfo Paoletti, Dr. David Kritchevsky

ISBN-10: 0120249197

ISBN-13: 9780120249190

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Arterial Proteoglycans as Lipoprotein-Retaining Agents The formation of soluble and insoluble associations between plasma lipoproteins and sulfated polysaccharides has been studied for more than 25 years. As mentioned before, the main motivation for further study lay in the histochemical findings, which showed in the atherosclerotic lesion a close spatial relation between the metachromatic regions and those taking up lipid stains. Bernfeld and collaborators conducted a detailed series of experiments that were designed to explore the structural parameters of natural or synthetic polysaccharides that were required for the formation of complexes with /3-lipoproteins.

1 ng cm - 2 hours -1 ) was significantly higher in atheromatous aortic intima than in normal segments. When the intima segments were extracted with saline and treated with collagenase, further apoB-containing hpoproteins were extracted, but they had little radioactivity; this result suggests the presence of slow-turnover pools of extracellular, matrix-bound apoB in the lesions. Lipoproteins and the Arterial Mesenchyme 31 We can summarize the evidence discussed in the preceding paragraphs by stating that apoB-containing lipoproteins continuously enter the intima and are accumulated extracellularly, especially in lesions.

063 of HR-LDL and LR-LDL. The most prominent difference between HR-LDL and LR-LDL was found during isoelectric focusing; HR-LDL was found at a more basic pH, demonstrating that at physiological pH the presence of a more positive net charge in the surface of LDL favors the interaction with proteoglycans. We have analyzed two fractions of the LDL of a single individual: one fraction is insolubilized by arterial LCP and one remains soluble. The insolubilized pellet was richer in free cholesterol than the supernatant fraction, and it showed a higher isoelectric point, which is probably associated with a lower content of TV-acetylneuraminic acid in the apoLDL.

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Advances in lipid research. / Volume 19 by Rodolfo Paoletti, Dr. David Kritchevsky


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