By David R. Gross DVM, PhD (auth.)

ISBN-10: 9401707308

ISBN-13: 9789401707305

ISBN-10: 9401707324

ISBN-13: 9789401707329

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Inhibited noradrenalineinduced increases in blood pressure and reflex bradycardia, partially antagonized isoprenaline-induced decrease in blood pressure with no effect on tachycardia, decreased then increased uptake of tritiated noradrenaline. 1:4 Rabbits Anesthetized with urethane (lglkg, (lg/kg, IV) plus 30 min. 1:5 Hamsters Anesthetized with pentobarbital (no dose given), exposed in vivo cheek pouch preparation, superfused with Krebs solution Dose response Dose-dependent arterioles dilation of 35 Same as above 10-8 to 109M superfusate Caused vasodilation but betaendorphan 55 x more potent net enkephalin 24x, leu enkephalin 20 x 133 Analgesia and sedation 2-5 mglkg, mg/kg, SC Effects within 15 min.

Decreased firing rate of type B neurons in both the nucleus tractus solitarii and the nucleus ambiguus. 5%) 70% N20, during a 2hr surgical preparation. 04 mglkg mg/kg 50 Ilglkg, Ilg/kg, Decreased mean aortic pressure and heart rate Anesthetized with ether, electrolytic decerebration, acute instrumentation, approx. Lglkg, IV Decreased heart rate and mean aortic pressure, decreased somato-cardiovascular reflexes (stimulation of a cut cutaneous nerve), mean aortic pressure returned to baseline in approx.

Lidocaine. 1 mg/kg, 1M IM No data 2 30 Chapter 2 Dose Conditions of the Experiment Cardiovascular Effects References Increased heart rate at 5 min. post injection but back to baseline at 15, 30 and 60 min. post injected. Cardiac output increased at 5 and 15 min. but same as baseline at 30 and 60 min. No change in pulmonary artery blood gases. No change in respiratory rate. 0 mg/kg,IM mg/kg, IM No cardiovascular data, onset of oI effect within 10 min. 3 mglkg No cardiovascular data - some monkeys may require as much as 11 mg/kg.

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Animal models in cardiovascular research by David R. Gross DVM, PhD (auth.)


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