By Kewal K. Jain

ISBN-10: 161779239X

ISBN-13: 9781617792397

For physicians, surgeons, and scientists engaged on cardiovascular issues, Applications of Biotechnology in Cardiovascular Therapeutics serves as a useful reference by means of accumulating the fundamental writings of Dr. Kewal ok. Jain at the themes of biotechnology as they relate to heart problems. This thorough quantity comprises such topics as biotechnology and healing supply to the cardiovascular method, cell-selective particular drug supply, telephone and gene remedies, together with antisense and RNA interference, state of the art gene treatment methods, in addition to customized cardiology as a fashion of integrating new applied sciences into the choice of the very best remedy for a person sufferer. chosen references from fresh literature are gathered for every bankruptcy, and the textual content is supplemented via a number of valuable tables and figures.

Comprehensive and up to date, Applications of Biotechnology in Cardiovascular Therapeutics should be greatly necessary for these operating in existence sciences and the pharmaceutical sciences, and the inclusion of a few fundamentals of cardiovascular illnesses will significantly gain nonmedical readers as well.

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Functional proteomic analyses will improve our understanding of the relations between proteome changes and cardiovascular dysfunctions. Study of Cardiac Mitochondrial Proteome in Myocardial Ischemia Myocardial ischemia-reperfusion induces mitochondrial dysfunction and, depending upon the degree of injury, may lead to cardiac cell death. However, Molecular Cardiology 11 ability to understand mitochondrial dysfunction has been hindered by an absence of molecular biomarkers defining the various degrees of injury.

The most common cause of PAD is arteriosclerosis obliterans − segmental arteriosclerotic narrowing or obstruction of the lumen of the arteries supplying the limbs. The lower limbs are involved more frequently than the upper limbs. Although not life threatening, this condition causes considerable pain and disability. There is overlap in the patient populations with various cardiovascular disorders. For example, hypertension is a risk factor for heart disease and can be found in patients with CAD.

This provides the foundation for rational and innovative approaches to cardiovascular therapeutics. Molecular Cardiology 9 Cardiogenomics The term cardiogenomics refers to the role of genes in cardiovascular system. Microarrays are being applied to study gene expression. The patterns in the variation of expression of many genes correlate well with the models currently used to explain the pathogenesis of cardiovascular diseases. More complete genomic maps allow easier identification of genes that cause monogenic inherited diseases.

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Applications of Biotechnology in Cardiovascular Therapeutics by Kewal K. Jain

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