By Icon Health Publications
It is a 3-in-1 reference publication. It provides a whole scientific dictionary overlaying hundreds of thousands of phrases and expressions in relation to arteriosclerosis. It additionally provides wide lists of bibliographic citations. eventually, it presents info to clients on tips on how to replace their wisdom utilizing quite a few web assets. The ebook is designed for physicians, scientific scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with learn devoted to arteriosclerosis. in case your time is effective, this e-book is for you. First, you won't waste time looking the web whereas lacking loads of proper info. moment, the publication additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing 1000s of web content.
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Additional info for Arteriosclerosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Studies will also investigate the efficacy of using ribozyme as a potential therapeutic agent by generating transgenic mouse expressing ribozyme. Studies will also address new approaches for gene delivery of multiple genes together by using helper-dependent adenovirus vector in vivo to evaluate the synergistic effect of this strategy on the treatment for hyperlipidemia. Taken together, these studies will provide understanding of target(s) underlying predisposition to atherogenesis. The study will shed new insights to the understanding of the structure/function of the apoB mRNA hammerhead ribozyme, and the possible application of using this ribozyme as a therapeutic agent for the treatment of atherosclerosis.
Our objective in this application is to define the unique role of the kallikrein-kinin system (KKS) in the pathogenesis of vascular complications and to elucidate the underlying mechanisms involved in this process. Our hypothesis which is based on preliminary data generated from the DCCT/EDIC-cohort of type 1 diabetic patients, demonstrate, for the first time, an association between plasma prekallikrein levels and surrogate markers of Studies 37 macrovascular disease (internal and common carotid intima-medial wall thickness).
The proposal described herein will test the hypothesis that viral vectors capable of transferring the human iNOS gene can suppress the development of CAV without causing undue toxicity to cardiac myocytes. Furthermore, this proposal will serve as the pre-clinical basis for near-term clinical trials for the future prevention of CAV in humans. In order to serve these ends, we will carry out the following Specific Aims: 1) to determine the efficacy of several viral vectors (adenoviral, adeno-associated virus, and lentivirus) containing the human iNOS gene (Ad-iNOS, AAV-iNOS, Lt-iNOS) and their respective control vectors for suppression of cardiac transplant arteriosclerosis in the rat model; 2) to determine toxicity of Ad-iNOS, AAV-iNOS, and Lt- iNOS and their respective control vectors in rat models; 3) to determine efficacy and toxicity of the ideal viral vector (Ad-iNOS, AAV-iNOS, or LtiNOS) and its respective control vector as determined in Specific Aim #2, in a porcine model of chronic rejection and 4) to determine the toxicity in human hearts that are being supported with ventricular assist devices.
Arteriosclerosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications